361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study demonstrates that the class I myosins Myo1e and Myo1f are essential for coordinating the spatiotemporal transition from protrusive podosomes to a contractile phagocytic ring, thereby ensuring efficient cup closure and preventing stalled engulfment or excessive trogocytosis during Fc-receptor-mediated phagocytosis in macrophages.
This paper introduces POCA, a unified, non-genetic photosensitizer platform that leverages standard immunofluorescence and in situ hybridization workflows to enable spatially resolved proximity labeling of proximal proteomes for diverse protein, RNA, and DNA targets within fixed cells.
This study demonstrates that the hydrolase activity of ABHD2 is not required for progesterone-induced CatSper-mediated calcium influx or hyperactivated motility in human sperm, challenging the previously proposed mechanism of progesterone action.
This study reveals that the centriculum, an ER-derived membrane reticulum surrounding *C. elegans* centrosomes, functions as a dynamic microtubule filter that regulates microtubule extension and stability through physical collisions, thereby influencing centrosome architecture and soluble tubulin concentration.
This study demonstrates that endogenous cell competition acts as a genome quality-control mechanism in zebrafish to eliminate pathogenic de novo mutant cells during development, but this protective surveillance is compromised under pH stress, leading to the persistence of harmful mutations and subsequent tissue defects.
This study introduces a genetic model in the short-lived African turquoise killifish to demonstrate that brain macrophages, particularly those resembling mammalian border-associated and monocyte-derived subsets, are responsible for clearing extracellular substrates but lose this engulfment capacity with age, offering a new platform for developing therapies against neurodegenerative diseases.
The paper identifies a new class of BAG2-driven, phase-separated organelles called Immune-Protein Degradation Bodies (I-PDBs) that link protein quality control to adaptive immunity by redirecting aggregated proteins to specialized sites for degradation and antigenic peptide generation, a mechanism termed the Proteostasis-Associated Immune Relay (PAIR).
This paper presents a rapid and cost-effective method for creating ~100 nm antibody-binding compensation beads to address the current lack of commercial options for nanoscale flow cytometry.
This paper describes a chemical biology strategy that uses synthetic lipid analogs with programmable tail structures to selectively manipulate, produce, and bioorthogonally label specific lipid classes within living mammalian cells without genetic or enzymatic intervention.
CD47 blockade promotes the resolution of atherosclerosis by qualitatively reprogramming the myeloid landscape, specifically by suppressing inflammatory monocyte recruitment while simultaneously enriching macrophage subsets with enhanced efferocytic capacity to clear apoptotic cells.